Los Angeles pulled Williams out at halftime with an ankle injury for the rest of the contest.
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He had just one catch for 15 yards in the first half, and again raised his health concerns when he came to the sidelines with the ball.
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Williams returned for the first time since October 23 in a loss to the Seattle Seahawks, his only catch, suffering another injury.
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It was Allen's third game of the season, as the five-time Pro Bowler struggled with stability concerns throughout the campaign.
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Justin Herbert has relied more heavily on Joshua Palmer as his other top receivers have been sidelined, and he looks set to do the same for contests against the rest of the Chiefs.
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As for Williams, he was limited to several practices leading up to the contest against the Chargers' division rivals.
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Health issues have prevented him from building on the career season he posted in 2021 with 76 catches for 1,146 yards and nine touchdowns.
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He is a deep threat on offense for Herbert, especially when outside and with Allen when he has more space.